Gregory Bock R.

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Environmental Statistics

Gregory Bock R.

Environmental Statistics

Environmental statistics is a rapidly growing discipline that is important not only as a division of professional and academic statistics, but also in the accumulation of data on environmental effects and in the formulation of environmental policy by government agencies. This book features contributions from policy makers, scientists actively involved in collection of data, and professional, academic and government statisticians. These explore the interfaces between the different areas of...

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Gregory Bock R.

The Nature and Origin of Amyloid Fi...

Gregory Bock R.

The Nature and Origin of Amyloid Fibrils

Amyloid fibrils are associated with a range of pathological disorders including Alzheimer's Disease, Down's syndrome, diabetes, cardiomyopathies, and transmissible spongiform encephalopathies. This volume is a comprehensive account of recent developments in the understanding of the process of amyloid fibrils. Contains up-to-date data on all of the clinical problems which, despite their pathological significance, are still largely unsolved.

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Gregory Bock R.

Biology of IGF-1

Gregory Bock R.

Biology of IGF-1

An invaluable book containing a series of interdisciplinary discussions between clinical and basic scientists. Biology of IGF-1: Its interaction with insulin and health and malignant states focuses on key issues such as: the definition of danger zones the development of methods for early recognition of malignant states linked to IGF-1 and/or insulin possible approaches to preventative intervention the relevance in this field of research to the development of novel therapeutic approaches to...

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Gregory Bock R.

Understanding Nicotine and Tobacco...

Gregory Bock R.

Understanding Nicotine and Tobacco Addiction

Cigarette smoking is estimated to lead to 4.9 million premature deaths per year worldwide. This is predicted to rise to 10 million by 2020. In western countries it kills half of all smokers who fail to stop. The prevailing model for tobacco addiction is that nicotine from cigarettes rewards smoking and punishes abstinence, tapping into a motivational system of operant conditioning that requires no conscious awareness. However, there are also accounts which involve cognitive biases and the effect...

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Gregory Bock R.

Growth Factors as Drugs for Neurolo...

Gregory Bock R.

Growth Factors as Drugs for Neurological and Sensory Disorders

Degeneration of sensory receptors or of the nerves innervating them leads to a sensory deficit. Various strategies have been tried for promoting regrowth of sensory receptors, particularly in the eye and ear. The latest data from experimental studies in animals are presented in the book including applications of BDNF and CNTF in the eye and epidermal growth factor in the ear.

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Gregory Bock R.

Higher-Order Processing in the Visu...

Gregory Bock R.

Higher-Order Processing in the Visual System

Foremost neurophysiologists and psychophysicists provide pertinent information on the nature of representation at the earliest stages as this will constrain the disposition of all subsequent processing. This processing is discussed in several different types of visual perception.

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Gregory Bock R.

Sensory Guidance of Movement

Gregory Bock R.

Sensory Guidance of Movement

Sensory Guidance of Movement Chairman: Mitchell Glickstein, 1998 In the past few years there has been an increasing recognition of the multiplicity of sensory and motor areas of the cerebral cortex. However, still relatively little is known about the way in which sensory areas are functionally linked to motor areas. On the basis of current anatomical evidence, there are three major pathways involved in this linking. One of these routes is by way of cortico-cortical links, beginning in the...

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Gregory Bock R.

Decoding the Genomic Control of Imm...

Gregory Bock R.

Decoding the Genomic Control of Immune Reactions

This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections. The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and...

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Gregory Bock R.

Immunoinformatics

Gregory Bock R.

Immunoinformatics

The astounding diversity of the immune system and the complexity of its regulatory pathways makes immunology a combinatorial science. Computational analysis has therefore become an essential element of immunology research and this has led to the creation of the emerging field of immunoinformatics. This book is the first to feature thorough coverage of this new field. Immunoinformatics facilitates the understanding of immune function by modelling the interactions among immunological components....

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Gregory Bock R.

Reversible Protein Acetylation

Gregory Bock R.

Reversible Protein Acetylation

A comprehensive review of recent work on chromatin and non-histone proteins, this book arises from the interactions of a multidisciplinary group of scientists involved in the study of acetylation. This area of research opens up new and exciting possibilities for drug design, and so the final chapters in the book examine some of the potential applications in the treatment of various diseases.

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Gregory Bock R.

Non-Reproductive Actions of Sex Ste...

Gregory Bock R.

Non-Reproductive Actions of Sex Steroids

Prominent clinicians and researchers from diverse disciplines discuss the basic cell and molecular biology of steroid action and sex steroids' effects on the nervous and immune systems. Provides an integrated evaluation of the advantages and disadvantages of hormone replacement therapy.

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Gregory Bock R.

Fatty Acid and Lipotoxicity in Obes...

Gregory Bock R.

Fatty Acid and Lipotoxicity in Obesity and Diabetes

The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic β cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle. This book...

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Gregory Bock R.

Empathy and Fairness

Gregory Bock R.

Empathy and Fairness

Empathy is the process that allows us to share the feelings and emotions of others, in the absence of any direct emotional stimulation to the self. Humans can feel empathy for other people in a wide array of contexts: for basic emotions and sensation such as anger, fear, sadness, joy, pain and lust as well as for more complex emotions such as guilt, embarrassment and love. It has been proposed that, for most people, empathy is the process that prevents us doing harm to others. Although empathy...

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Gregory Bock R.

Genetics of Autoimmunity

Gregory Bock R.

Genetics of Autoimmunity

This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated. Incorporating data on disease-associated chromosomal loci that has been accumulated from inbred mice, the title: descibes how some susceptibility loci may be common to many diseases, whereas others are relatively disease specific discusses the importance of developing...

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Gregory Bock R.

Tissue Engineering of Cartilage and...

Gregory Bock R.

Tissue Engineering of Cartilage and Bone

Tissue engineering takes advantages of the combined use of cultured living cells and three-dimensional scaffolds to reconstruct adult tissues that are absent or malfunctioning. This book brings together scientists and clinicians working on a variety of approaches for regenerating of damaged or lost cartilage and bone to assess the progress of this dynamic field. In its early days, tissue engineering was driven by material scientists who designed novel bio-resorbable scaffolds on which to seed...

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Gregory Bock R.

The Limits of Reductionism in Biolo...

Gregory Bock R.

The Limits of Reductionism in Biology

A comprehensive volume examining the fundamental questions raised by reductionists' theory about levels of explanation necessary to understand biological systems. The book evaluates the enormously powerful techniques of molecular biology, and analyzes precisely how molecular information has improved our understanding of fundamental biological processes.

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Gregory Bock R.

The Molecular Basis of Cellular Def...

Gregory Bock R.

The Molecular Basis of Cellular Defence Mechanisms

The field of lymphokine research has grown in parallel to the exciting developments around the two sets of cells which defend the body. While lymphokines are the «property» of immunologists, the molecular regulators of hemopoiesis (CSFs) belong to the hematologists. This book offers the rare opportunity to examine these separate fields of expertise together.

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Gregory Bock R.

New Treatment Strategies for Dengue...

Gregory Bock R.

New Treatment Strategies for Dengue and Other Flaviviral Diseases

Dengue virus is a member of the Flaviviridae family, which includes viruses associated with human diseases such as yellow fever, Japanese encephalitis and hepatitis C. Dengue fever is transmitted by mosquitoes, principally Aedes aegypti. There are four serotypes of dengue virus, of which DENV-2 has been the most prevalent in many recent epidemics. Following primary infection, lifelong immunity develops, preventing repeated assault by the same serotype. However, the non-neutralizing antibodies...

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Gregory Bock R.

Tinkering

Gregory Bock R.

Tinkering

Much recent research in evolutionary developmental biology has focused on the origin of new body plans. However, most evolutionary change at the population and species level consists of tinkering: small-scale alterations in developmental pathways within a single body plan. Such microevolutionary events have been well studied on a population genetic level and from the perspective of adaptive phenotypic evolution, but their developmental mechanisms remain poorly studied. This book explores both...

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Gregory Bock R.

Stem Cells

Gregory Bock R.

Stem Cells

Understanding stem cells at the molecular level is essential to understanding their behaviour in a physiological context. This volume in our acclaimed Novartis Foundation series features animated discussion from the world’s experts in this topic on the important ethical issues that are raised by research on stem cells. They review the various regulatory regimes, which apply in different countries – a key factor in determining where future stem cell research is carried out. Potential clinical...

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Gregory Bock R.

Plasminogen-Related Growth Factors

Gregory Bock R.

Plasminogen-Related Growth Factors

A timely volume dealing with the evolutionary and structural links between the clotting and fibrinolytic proteins and plasminogen-related growth factors. The role of individual domains for enzymatic proteins and plasminogen-related growth factors is also comprehensively examined.

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Gregory Bock R.

Precision Agriculture

Gregory Bock R.

Precision Agriculture

This book investigates new agricultural systems such as organic and green manuring, as well as integrated pest management practices, and looks at how they can improve farm productivity against the enhancements for the environment. Much of the information presented focuses on microinvestigation of the soil, and on the effects of soil variability within fields on yields and nutrient flows.

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Gregory Bock R.

Anaphylaxis

Gregory Bock R.

Anaphylaxis

Anaphylaxis is an immediate-type allergic reaction involving the whole organism. It is the most life-threatening allergic condition. Although there are few exact epidemiological data regarding prevalence, estimates regarding insect sting anaphylaxis range from 1-3% in the general population, but much higher values have been reported by some authors for food and drug-induced anaphylaxis. Anaphylaxis is the main acute killer of allergic individuals. Although anaphylaxis was discovered at the...

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Gregory Bock R.

Dietary Supplements and Health

Gregory Bock R.

Dietary Supplements and Health

Dietary supplements can contain a wide variety of ingredients, either singly or in combination, including nutrients, botanicals and 'bioactive components' commonly found in foods. They are marketed and used by consumers for a range of reasons: to enhance «well-being», as traditional medicines, for health promotion or disease risk reduction, and as alternatives or complements to conventional drug therapies. On a global basis, the dietary supplement industry has enjoyed rapid growth, becoming a...

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Gregory Bock R.

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