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Biocatalysts and Enzyme Technology

Klaus Buchholz

Biocatalysts and Enzyme Technology

This second edition of a bestselling textbook offers an instructive and comprehensive overview of our current knowledge of biocatalysis and enzyme technology. The book now contains about 40% more printed content. Three chapters are completely new, while the others have been thoroughly updated, and a section with problems and solutions as well as new case studies have been added. Following an introduction to the history of enzyme applications, the text goes on to cover in depth enzyme mechanisms...

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Klaus Buchholz

Illicit Drugs in the Environment

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Illicit Drugs in the Environment

Illicit drugs are an emerging class of environmental contaminants and mass spectrometry is the technique of choice for their analysis. This landmark reference discusses the analytical techniques used to detect illicit drugs in wastewater and surface water, details how to estimate the levels of contaminants in the environment, and explores the behavior, fate, and toxic effects of this new class of contaminants, now a ubiquitous presence in wastewater and surface water. The book details how an...

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Chemische Grenzwerte

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Chemische Grenzwerte

Nach welchen Kriterien legt man Grenzwerte fur Chemikalien – ob am Arbeitsplatz, im Haushalt oder in der Umwelt – fest? Ein Frage, deren Aktualitat nicht nur fur Wissenschaftler, sondern auch fur die Bevolkerung immens zunimmt und die sich nicht einseitig aus der Sicht der Naturwissenschaft beantworten la?t. Stichworte wie subjektive Risikowahrnehmung, intuitive Toxikologie oder erkenntnistheoretische Aspekte des «wahren Me?wertes» zeigen, da? hier auch Juristen, Soziologen, Philosophen und...

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Understanding Distillation Using Co...

Mark Peters

Understanding Distillation Using Column Profile Maps

Researchers share their pioneering graphical method for designing almost any distillation structure Developed by the authors in collaboration with other researchers at the Centre of Material and Process Synthesis, column profile maps (CPMs) enable chemical engineers to design almost any distillation structure using novel graphical techniques. The CPM method offers tremendous advantages over other design methods because it is generalized and not constrained to a particular piece of equipment....

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Mark Peters

Practical Approaches to Method Vali...

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Practical Approaches to Method Validation and Essential Instrument Qualification

Practical approaches to ensure that analytical methods and instruments meet GMP standards and requirements Complementing the authors' first book, Analytical Method Validation and Instrument Performance Verification, this new volume provides coverage of more advanced topics, focusing on additional and supplemental methods, instruments, and electronic systems that are used in pharmaceutical, biopharmaceutical, and clinical testing. Readers will gain new and valuable insights that enable them to...

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Supported Ionic Liquids

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Supported Ionic Liquids

This unique book gives a timely overview about the fundamentals and applications of supported ionic liquids in modern organic synthesis. It introduces the concept and synthesis of SILP materials and presents important applications in the field of catalysis (e.g. hydroformylation, hydrogenation, coupling reactions, fine chemical synthesis) as well as energy technology and gas separation. Written by pioneers in the field, this book is an invaluable reference book for organic chemists in academia...

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Handbook of Formulating Dermal Appl...

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Handbook of Formulating Dermal Applications

The conceptualization and formulation of skin care products intended for topical use is a multifaceted and evolving area of science. Formulators must account for myriad skin types, emerging opportunities for product development as well as a very temperamental retail market. Originally published as “Apply Topically” in 2013 (now out of print), this reissued detailed and comprehensive handbook offers a practical approach to the formulation chemist’s day-to-day endeavors by: • Addressing the...

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Synthetic Methods for Biologically...

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Synthetic Methods for Biologically Active Molecules

This useful reference focuses on the currently available toolbox of bio-catalysed reductions of C=O, C=C and formal C=N bonds to show which transformations can be reliably used in manufacturing processes and which still require improvements. Following an introductory chapter, chapters 2-4 present the synthetic strategies that are currently available for the reduction of C=C and C=O bonds and for reductive amination, by means of whole-cell catalysts and isolated enzymes. Chapters 5-7 go on to...

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Evaluation of Enzyme Inhibitors in...

Robert A. Copeland

Evaluation of Enzyme Inhibitors in Drug Discovery

Offers essential guidance for discovering and optimizing novel drug therapies Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and...

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Robert A. Copeland

Selective Nanocatalysts and Nanosci...

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Selective Nanocatalysts and Nanoscience

Filling a gap in the catalysis and nano literature, this monograph is unique in focusing on both nanostructured heterogeneous and homogeneous catalysis. As such, it describes a selection of heterogeneous catalysts in use, showing that the dimension of the relevant portions of the catalysts are always in the 1-100 nm range, and so may be properly understood as nanomachines for the chemical manipulation of molecules to perform high precision selective synthesis. The prominent international authors...

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Understanding Organometallic Reacti...

Valentin P. Ananikov

Understanding Organometallic Reaction Mechanisms and Catalysis

Exploring and highlighting the new horizons in the studies of reaction mechanisms that open joint application of experimental studies and theoretical calculations is the goal of this book. The latest insights and developments in the mechanistic studies of organometallic reactions and catalytic processes are presented and reviewed. The book adopts a unique approach, exemplifying how to use experiments, spectroscopy measurements, and computational methods to reveal reaction pathways and molecular...

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Valentin P. Ananikov

Single-Molecule Biophysics

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Single-Molecule Biophysics

Discover the experimental and theoretical developments in optical single-molecule spectroscopy that are changing the ways we think about molecules and atoms The Advances in Chemical Physics series provides the chemical physics field with a forum for critical, authoritative evaluations of advances in every area of the discipline. This latest volume explores the advent of optical single-molecule spectroscopy, and how atomic force microscopy has empowered novel experiments on individual...

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Anion Coordination Chemistry

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Anion Coordination Chemistry

Building on the pioneering work in supramolecular chemistry from the last 20 years or so, this monograph addresses new and recent approaches to anion coordination chemistry. Synthesis of receptors, biological receptors and metallareceptors, the energetics of anion binding, molecular structures of anion complexes, sensing devices are presented and computational studies addressed to aid with the understanding of the different driving forces responsible for anion complexation. The reader is...

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Separation of Enantiomers

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Separation of Enantiomers

In one handy volume this handbook summarizes the most common synthetic methods for the separation of racemic mixtures, allowing an easy comparison of the different strategies described in the literature. Alongside classical methods, the authors also consider kinetic resolutions, dynamic kinetic resolutions, divergent reactions of a racemic mixture, and a number of «neglected» cases not covered elsewhere, such as the use of circularly polarized light, polymerizations, «ripening» processes,...

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Renewable Raw Materials

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Renewable Raw Materials

One of the main challenges facing the chemical industry is the transition to sustainable operations. Industries are taking initiatives to reduce resource intensities or footprints, and by adopting safer materials and processes. Such efforts need to be supported by techniques that can quantify the broad economic and environmental implications of industrial operations, retrofi t options and provide new design alternatives. This contemporary overview focuses on cradle-to-grave life cycle...

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Handbook of Fluorescence Spectrosco...

Jörg Enderlein

Handbook of Fluorescence Spectroscopy and Imaging

Providing much-needed information on fluorescence spectroscopy and microscopy, this ready reference covers detection techniques, data registration, and the use of spectroscopic tools, as well as new techniques for improving the resolution of optical microscopy below the resolution gap. Starting with the basic principles, the book goes on to treat fluorophores and labeling, single-molecule fluorescence spectroscopy and enzymatics, as well as excited state energy transfer, and super-resolution...

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Jörg Enderlein

Testing Adhesive Joints

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Testing Adhesive Joints

Joining techniques such as welding, brazing, riveting and screwing are used by industry all over the world on a daily basis. A further method of joining has also proven to be highly successful: adhesive bonding. Adhesive bonding technology has an extremely broad range of applications. And it is difficult to imagine a product – in the home, in industry, in transportation, or anywhere else for that matter – that does not use adhesives or sealants in some manner. The book focuses on the methodology...

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Selective Glycosylations

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Selective Glycosylations

A comprehensive summary of novel approaches to the stereoselective construction of glycosidic linkages, covering modern glycosylation methods and their use and application in natural product synthesis and drug discovery. Clearly divided into five sections, the first describes recent advances in classical methodologies in carbohydrate chemistry, while the second goes on to deal with newer chemistries developed to control selectivity in glycosylation reactions. Section three is devoted to...

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Collaborative Computational Technol...

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Collaborative Computational Technologies for Biomedical Research

Methods, Processes, and Tools for Collaboration «The time has come to fundamentally rethink how we handle the building of knowledge in biomedical sciences today. This book describes how the computational sciences have transformed into being a key knowledge broker, able to integrate and operate across divergent data types.»—Bryn Williams-Jones, Associate Research Fellow, Pfizer The pharmaceutical industry utilizes an extended network of partner organizations in order to discover and develop new...

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Cluster Secondary Ion Mass Spectrom...

Christine M. Mahoney

Cluster Secondary Ion Mass Spectrometry

Explores the impact of the latest breakthroughs in cluster SIMS technology Cluster secondary ion mass spectrometry (SIMS) is a high spatial resolution imaging mass spectrometry technique, which can be used to characterize the three-dimensional chemical structure in complex organic and molecular systems. It works by using a cluster ion source to sputter desorb material from a solid sample surface. Prior to the advent of the cluster source, SIMS was severely limited in its ability to characterize...

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Christine M. Mahoney

Plant-Based Natural Products

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Plant-Based Natural Products

Intense research has been started all around the world in the past few decades to exploit different agents from natural products as eco-friendly alternative to synthetic and toxic chemicals. Natural products and their derivatives have received increasing attention for their use in many everyday applications ranging from food, medicine, textiles, and healthcare.This new book presents significant research advances about the use of natural products, mainly plant colorants, bioactive compounds and...

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Homogeneous Catalysis for Unreactiv...

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Homogeneous Catalysis for Unreactive Bond Activation

This book offers a comprehensive overview of different catalytic reactions applied to the activation of chemical bonds. Each of the seven chapters covers key C-X classes where carbon is combined with another element: chlorine, fluorine, nitrogen, sulfur, oxygen, hydrogen, and carbon. The first part of the book discusses homogeneous catalysis in the activation and transformation of C-Cl and C-F, highlighting their basic activation modes, cross-coupling, and intensive mechanisms. The second part...

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Experimente rund um die Kunststoffe...

Prof. Georg Schwedt

Experimente rund um die Kunststoffe des Alltags

Joghurtbecher, Frischhaltefolien, Plastikbeutel, Parkbanke, Warmedammungs- und Verpackungsmaterialien und, und, und … ohne Kunststoffe geht es in unserem Alltag nicht! Georg Schwedt, erfolgreicher Sach- und Lehrbuchautor, prasentiert ein neues und in seiner Thematik einzigartiges Experimente-Buch. Seit mehreren Jahrzehnten wirbt Georg Schwedt fur die Chemie. Den Aufbau und Betrieb mehrerer Mitmachlabors hat er ma?geblich initiiert und mitgestaltet – die daraus gewonnene Erfahrung flie?t auch in...

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Prof. Georg Schwedt

How To Solve Organic Reaction Mecha...

Mark G. Moloney

How To Solve Organic Reaction Mechanisms

How To Solve Organic Reaction Mechanisms: A Stepwise Approach is an upgraded and much-expanded sequel to the bestselling text Reaction Mechanisms at a Glance. This book takes a unique approach to show that a general problem-solving strategy is applicable to many of the common reactions of organic chemistry, demonstrating that logical and stepwise reasoning, in combination with a good understanding of the fundamentals, is a powerful tool to apply to the solution of problems. Sub-divided by...

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Mark G. Moloney

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