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24566 кн.
Cytogenetics is the study of chromosome morphology, structure, pathology, function, and behavior. The field has evolved to embrace molecular cytogenetic changes, now termed cytogenomics. Cytogeneticists utilize an assortment of procedures to investigate the full complement of chromosomes and/or a targeted region within a specific chromosome in metaphase or interphase. Tools include routine analysis of G-banded chromosomes, specialized stains that address specific chromosomal structures, and...
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This book is a unique guide to emerging stem cell technologies and the opportunities for their commercialisation. It provides in-depth analyses of the science, business, legal, and financing fundamentals of stem cell technologies, offering a holistic assessment of this emerging and dynamic segment of the field of regenerative medicine. • Reviews the very latest advances in the technology and business of stem cells used for therapy, research, and diagnostics • Identifies key challenges to the...
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Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of «personalized drugs» are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of...
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This book reflects the increasing interest among the chemical synthetic community in the area of asymmetric copper-catalyzed reactions, and introduces readers to the latest, most significant developments in the field. The contents are organized according to reaction type and cover mechanistic and spectroscopic aspects as well as applications in the synthesis of natural products. A whole chapter is devoted to understanding how primary organometallics interact with copper to provide selective...
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Published by the American Geophysical Union as part of the Geophysical Monograph Series, Volume 198. Climates, Landscapes, and Civilizations brings together a collection of studies on the history of complex interrelationships between humans and their environment by integrating Earth science with archeology and anthropology. At a time when climate change, overpopulation, and scarcity of resources are increasingly affecting our ways of life, the lessons of the past provide multiple reference...
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2017 PROSE Award Honorable Mention The PROSE Awards draw attention to pioneering works of research and for contributions to the conception, production, and design of landmark works in their fields. Featuring peer-reviewed contributions from noted experts in their fields of research, Reproducibility: Principles, Problems, Practices, and Prospects presents state-of-the-art approaches to reproducibility, the gold standard of sound science, from multi- and interdisciplinary perspectives. Including...
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Transport systems are facing an impossible dilemma: satisfy an increasing demand for mobility of people and goods, while decreasing their fossil-energy requirements and preserving the environment. Additionally, transport has an opportunity to evolve in a changing world, with new services, technologies but also new requirements (fast delivery, reliability, improved accessibility). The subject of traffic is organized into two separate but complementary volumes: Volume 3 on Traffic Management and...
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Microstructural Geochronology Geochronology techniques enable the study of geological evolution and environmental change over time. This volume integrates two aspects of geochronology: one based on classical methods of orientation and spatial patterns, and the other on ratios of radioactive isotopes and their decay products. The chapters illustrate how material science techniques are taking this field to the atomic scale, enabling us to image the chemical and structural record of mineral lattice...
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Solar cooling systems can be a cost-effective and environmentally attractive air-conditioning solution. The design of such systems, however, is complex. Research carried out under the aegis of the International Energy Agency's Solar Heating and Cooling Program has shown that there is a range of seemingly subtle design decisions that can impact significantly on the performance of solar cooling systems. In order to reduce the risk of errors in the design process, this guide provides detailed and...
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The Journal of Prosthodontics has been the official publication of the American College of Prosthodontics for more than 20 years. In excess of 1,000 peer-reviewed articles on a wide variety of subjects are now in print, representing a treasure chest of history and valuable information on a myriad of topics of interest to the specialty of prosthodontics. Journal of Prosthodontics on Dental Implants is a “best of” compilation of the journal’s articles from a number of years, focusing exclusively...
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A comprehensive review of the state of the art in the control of multi-agent systems theory and applications The superiority of multi-agent systems over single agents for the control of unmanned air, water and ground vehicles has been clearly demonstrated in a wide range of application areas. Their large-scale spatial distribution, robustness, high scalability and low cost enable multi-agent systems to achieve tasks that could not successfully be performed by even the most sophisticated single...
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Natural Products: Discourse, Diversity and Design provides an informative and accessible overview of discoveries in the area of natural products in the genomic era, bringing together advances across the kingdoms. As genomics data makes it increasingly clear that the genomes of microbes and plants contain far more genes for natural product synthesis than had been predicted from the numbers of previously identified metabolites, the potential of these organisms to synthesize diverse natural...
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A practical and conceptual guide to treating depression using both Beckian CBT and the latest, cutting-edge third wave CBT approaches, including mindfulness and metacognitive therapy. It provides an understanding of depression and its treatment and a clear practical guidance on how to use each treatment approach. Covers CBT, metacognitive therapy, and third-wave behavioural approaches within one volume Presents the theoretical background and evidence for each approach, and describes application...
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Addresses the methodology and theoretical foundation of battery manufacturing, service and management systems (BM2S2), and discusses the issues and challenges in these areas This book brings together experts in the field to highlight the cutting edge research advances in BM2S2 and to promote an innovative integrated research framework responding to the challenges. There are three major parts included in this book: manufacturing, service, and management. The first part focuses on battery...
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The second edition of a highly acclaimed handbook and ready reference. Unmatched in its breadth and quality, around 100 specialists from all over the world share their up-to-date expertise and experiences, including hundreds of protocols, complete with explanations, and hitherto unpublished troubleshooting hints. They cover all modern techniques for the handling, analysis and modification of RNAs and their complexes with proteins. Throughout, they bear the practising bench scientist in mind,...
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Gas hydrates, or clathrate hydrates, are crystalline solids resembling ice, in which small (guest) molecules, typically gases, are trapped inside cavities formed by hydrogen-bonded water (host) molecules. They form and remain stable under low temperatures – often well below ambient conditions – and high pressures ranging from a few bar to hundreds of bar, depending on the guest molecule. Their presence is ubiquitous on Earth, in deep-marine sediments and in permafrost regions, as well as in...
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A Companion to Hong Kong Cinema provides the first comprehensive scholarly exploration of this unique global cinema. By embracing the interdisciplinary approach of contemporary film and cultural studies, this collection navigates theoretical debates while charting a new course for future research in Hong Kong film. Examines Hong Kong cinema within an interdisciplinary context, drawing connections between media, gender, and Asian studies, Asian regional studies, Chinese language and cultural...
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This innovative new handbook offers a comprehensive overview of the ways in which domestic education policy is framed and influenced by global institutions and actors. Surveys current debates about the role of education in a global polity, highlights key transnational policy actors, accessibly introduces research methodologies, and outlines global agendas for education reform Includes contributions from an international cast of established and emerging scholars at the forefront of the field...
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Provides comprehensive coverage on recidivism risk/needs assessment tools Correctional and healthcare professionals around the world utilize structured instruments referred to as risk/needs assessment tools to predict the likelihood that an offender will recidivate. Such tools have been found to provide accurate and reliable evaluations and are widely used to assess, manage, and monitor offenders both institutionally as well as in the community. By identifying offenders in need of different...
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The drive towards environmentally friendly buildings and infrastructure has led to a growing interest in providing design solutions underpinned by the core principles of sustainability to balance economic, social and environmental factors. Design Economics for the Built Environment: Impact of sustainability on project evaluation presents new directions, reflecting the need to recognise the impact of climate change and the importance of sustainability in project evaluation. The aim is to provide...
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Strong academic advising has been found to be a key contributor to student persistence (Center for Public Education, 2012), and many are expected to play an advising role, including academic, career, and faculty advisors; counselors; tutors; and student affairs staff. Yet there is little training on how to do so. Various advising strategies exist, each of which has its own proponents. To serve increasingly complex higher education institutions around the world and their diverse student cohorts,...
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Using a collaborative and interdisciplinary author base with experience in the pharmaceutical industry and academia, this book is a practical resource for high content (HC) techniques. • Instructs readers on the fundamentals of high content screening (HCS) techniques • Focuses on practical and widely-used techniques like image processing and multiparametric assays • Breaks down HCS into individual modules for training and connects them at the end • Includes a tutorial chapter that works through...
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This book addresses different algorithms and applications based on the theory of multiobjective goal attainment optimization. In detail the authors show as the optimal asset of the energy hubs network which (i) meets the loads, (ii) minimizes the energy costs and (iii) assures a robust and reliable operation of the multicarrier energy network can be formalized by a nonlinear constrained multiobjective optimization problem. Since these design objectives conflict with each other, the solution of...
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Water, energy and food are key resources to sustain life, and are the fundamental to national, regional and global economies. These three resources are interlinked in multiple ways, and the term “nexus” captures the interconnections. The nexus has been discussed, debated, researched, and advocated widely but the focus is often on the pairings of “water-energy” or “water-food” or “energy-food”. To really benefit from the nexus approach in terms of resource use efficiency it is essential to...
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