Gregory Bock R.

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Understanding Nicotine and Tobacco...

Gregory Bock R.

Understanding Nicotine and Tobacco Addiction

Cigarette smoking is estimated to lead to 4.9 million premature deaths per year worldwide. This is predicted to rise to 10 million by 2020. In western countries it kills half of all smokers who fail to stop. The prevailing model for tobacco addiction is that nicotine from cigarettes rewards smoking and punishes abstinence, tapping into a motivational system of operant conditioning that requires no conscious awareness. However, there are also accounts which involve cognitive biases and the effect...

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Gregory Bock R.

Tissue Engineering of Cartilage and...

Gregory Bock R.

Tissue Engineering of Cartilage and Bone

Tissue engineering takes advantages of the combined use of cultured living cells and three-dimensional scaffolds to reconstruct adult tissues that are absent or malfunctioning. This book brings together scientists and clinicians working on a variety of approaches for regenerating of damaged or lost cartilage and bone to assess the progress of this dynamic field. In its early days, tissue engineering was driven by material scientists who designed novel bio-resorbable scaffolds on which to seed...

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Gregory Bock R.

Tinkering

Gregory Bock R.

Tinkering

Much recent research in evolutionary developmental biology has focused on the origin of new body plans. However, most evolutionary change at the population and species level consists of tinkering: small-scale alterations in developmental pathways within a single body plan. Such microevolutionary events have been well studied on a population genetic level and from the perspective of adaptive phenotypic evolution, but their developmental mechanisms remain poorly studied. This book explores both...

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Gregory Bock R.

The Nature and Origin of Amyloid Fi...

Gregory Bock R.

The Nature and Origin of Amyloid Fibrils

Amyloid fibrils are associated with a range of pathological disorders including Alzheimer's Disease, Down's syndrome, diabetes, cardiomyopathies, and transmissible spongiform encephalopathies. This volume is a comprehensive account of recent developments in the understanding of the process of amyloid fibrils. Contains up-to-date data on all of the clinical problems which, despite their pathological significance, are still largely unsolved.

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Gregory Bock R.

The Molecular Basis of Cellular Def...

Gregory Bock R.

The Molecular Basis of Cellular Defence Mechanisms

The field of lymphokine research has grown in parallel to the exciting developments around the two sets of cells which defend the body. While lymphokines are the «property» of immunologists, the molecular regulators of hemopoiesis (CSFs) belong to the hematologists. This book offers the rare opportunity to examine these separate fields of expertise together.

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Gregory Bock R.

The Limits of Reductionism in Biolo...

Gregory Bock R.

The Limits of Reductionism in Biology

A comprehensive volume examining the fundamental questions raised by reductionists' theory about levels of explanation necessary to understand biological systems. The book evaluates the enormously powerful techniques of molecular biology, and analyzes precisely how molecular information has improved our understanding of fundamental biological processes.

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Gregory Bock R.

Stem Cells

Gregory Bock R.

Stem Cells

Understanding stem cells at the molecular level is essential to understanding their behaviour in a physiological context. This volume in our acclaimed Novartis Foundation series features animated discussion from the world’s experts in this topic on the important ethical issues that are raised by research on stem cells. They review the various regulatory regimes, which apply in different countries – a key factor in determining where future stem cell research is carried out. Potential clinical...

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Gregory Bock R.

Signalling Networks in Cell Shape a...

Gregory Bock R.

Signalling Networks in Cell Shape and Motility

This book features contributions from experts in cell biology, genetics, neurobiology, immunology and structural biology. The unifying element is that they all study processes of cell shape change and motility. Several key questions in this field of research are discussed: What are the organising principles behind cell shape change? Are there ‘master switches’ present in every cell type? How are extracellular signals interpreted by the cell in order to activate intracellular mechanisms? What is...

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Gregory Bock R.

Sensory Guidance of Movement

Gregory Bock R.

Sensory Guidance of Movement

Sensory Guidance of Movement Chairman: Mitchell Glickstein, 1998 In the past few years there has been an increasing recognition of the multiplicity of sensory and motor areas of the cerebral cortex. However, still relatively little is known about the way in which sensory areas are functionally linked to motor areas. On the basis of current anatomical evidence, there are three major pathways involved in this linking. One of these routes is by way of cortico-cortical links, beginning in the...

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Gregory Bock R.

Reversible Protein Acetylation

Gregory Bock R.

Reversible Protein Acetylation

A comprehensive review of recent work on chromatin and non-histone proteins, this book arises from the interactions of a multidisciplinary group of scientists involved in the study of acetylation. This area of research opens up new and exciting possibilities for drug design, and so the final chapters in the book examine some of the potential applications in the treatment of various diseases.

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Gregory Bock R.

Precision Agriculture

Gregory Bock R.

Precision Agriculture

This book investigates new agricultural systems such as organic and green manuring, as well as integrated pest management practices, and looks at how they can improve farm productivity against the enhancements for the environment. Much of the information presented focuses on microinvestigation of the soil, and on the effects of soil variability within fields on yields and nutrient flows.

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Gregory Bock R.

Plasminogen-Related Growth Factors

Gregory Bock R.

Plasminogen-Related Growth Factors

A timely volume dealing with the evolutionary and structural links between the clotting and fibrinolytic proteins and plasminogen-related growth factors. The role of individual domains for enzymatic proteins and plasminogen-related growth factors is also comprehensively examined.

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Gregory Bock R.

Novel and Re-emerging Respiratory V...

Gregory Bock R.

Novel and Re-emerging Respiratory Viral Diseases

The past decade has seen mounting global concern regarding viral outbreaks such as SARS, avian influenza and West Nile virus. In 2004 and 2005, reports of bird-to-human, and possible human-to-human, transmissions of the H5N1 influenza viruses raised fears that these viruses could cause a pandemic on the scale of the Spanish flu pandemic of 1918. Previous to this, a novel coronavirus had been identified as the aetiological agent of the severe acute respiratory syndrome (SARS), a new respiratory...

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Gregory Bock R.

Non-Reproductive Actions of Sex Ste...

Gregory Bock R.

Non-Reproductive Actions of Sex Steroids

Prominent clinicians and researchers from diverse disciplines discuss the basic cell and molecular biology of steroid action and sex steroids' effects on the nervous and immune systems. Provides an integrated evaluation of the advantages and disadvantages of hormone replacement therapy.

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Gregory Bock R.

New Treatment Strategies for Dengue...

Gregory Bock R.

New Treatment Strategies for Dengue and Other Flaviviral Diseases

Dengue virus is a member of the Flaviviridae family, which includes viruses associated with human diseases such as yellow fever, Japanese encephalitis and hepatitis C. Dengue fever is transmitted by mosquitoes, principally Aedes aegypti. There are four serotypes of dengue virus, of which DENV-2 has been the most prevalent in many recent epidemics. Following primary infection, lifelong immunity develops, preventing repeated assault by the same serotype. However, the non-neutralizing antibodies...

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Gregory Bock R.

Molecular Mechanisms Influencing Ag...

Gregory Bock R.

Molecular Mechanisms Influencing Aggressive Behaviours

This book features scientists from a broad spectrum of disciplines discussing recent data on aggression in laboratory animals with particular reference to possible implications for understanding human aggression. Chapters focus on the major current experimental issues in the study of aggression in humans and animals. The extensive discussions deal with specific problems of interpretation at the molecular level, as well as general issues relating to our understanding of human and animal...

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Gregory Bock R.

Molecular Approaches to Human Polyg...

Gregory Bock R.

Molecular Approaches to Human Polygenic Disease

Many common human diseases have a multifactorial origin: they are influenced by a person's genetic predisposition as well as by factors in the environment. This volume deals with the application of recombinant DNA techniques to the identification of diseases that have more than one inherited component. Focus is on the polygenic factors responsible for coronary atherosclerosis. Several other disorders having a polygenic origin are also discussed, including hypertension, diabetes mellitus,...

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Gregory Bock R.

Immunological Tolerance

Gregory Bock R.

Immunological Tolerance

This book brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Careful consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T cell activation during tumour...

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Gregory Bock R.

Immunoinformatics

Gregory Bock R.

Immunoinformatics

The astounding diversity of the immune system and the complexity of its regulatory pathways makes immunology a combinatorial science. Computational analysis has therefore become an essential element of immunology research and this has led to the creation of the emerging field of immunoinformatics. This book is the first to feature thorough coverage of this new field. Immunoinformatics facilitates the understanding of immune function by modelling the interactions among immunological components....

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Gregory Bock R.

Higher-Order Processing in the Visu...

Gregory Bock R.

Higher-Order Processing in the Visual System

Foremost neurophysiologists and psychophysicists provide pertinent information on the nature of representation at the earliest stages as this will constrain the disposition of all subsequent processing. This processing is discussed in several different types of visual perception.

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Gregory Bock R.

Heart Failure

Gregory Bock R.

Heart Failure

Heart failure is the main cause of death and disability in the industrialized world. There is a major need for novel therapeutics for prevention and reversal of cardiac pathology associated with heart failure and cardiac enlargement. Over recent years, dramatic progress has been made in unravelling the cellular circuitry involved in cardiac failure, as well as in normal cardiac growth, development and apoptosis. This work has revealed new and unexpected therapeutic targets in the heart. In...

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Gregory Bock R.

Growth Factors as Drugs for Neurolo...

Gregory Bock R.

Growth Factors as Drugs for Neurological and Sensory Disorders

Degeneration of sensory receptors or of the nerves innervating them leads to a sensory deficit. Various strategies have been tried for promoting regrowth of sensory receptors, particularly in the eye and ear. The latest data from experimental studies in animals are presented in the book including applications of BDNF and CNTF in the eye and epidermal growth factor in the ear.

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Gregory Bock R.

Genetics of Criminal and Antisocial...

Gregory Bock R.

Genetics of Criminal and Antisocial Behaviour

This book offers a fresh perspective on the controversial topic of criminal and antisocial behavior. It synthesizes findings from behavioral and population genetics, evolutionary biology and criminology and presents the latest findings in twin studies, adoption cohort studies, molecular genetics and animal models for human aggression. Also included is a detailed analysis of the legal implications of genetics and crime research and strategies for rehabilitation.

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Gregory Bock R.

Genetics of Autoimmunity

Gregory Bock R.

Genetics of Autoimmunity

This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated. Incorporating data on disease-associated chromosomal loci that has been accumulated from inbred mice, the title: descibes how some susceptibility loci may be common to many diseases, whereas others are relatively disease specific discusses the importance of developing...

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Gregory Bock R.

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